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KMID : 0370220080520040252
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Yakhak Hoeji
2008 Volume.52 No. 4 p.252 ~ p.258
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The Cytotoxic Effect of Benzoic Acid and Related Compounds against Oral Cancer Cell Lines
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Han Du-Seok
Park Yeun-Kju
Kang Jeong-Il
Baek Seung-Hwa
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Abstract
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The cytotoxic effect of benzoic acid and related compounds on the growth of normal cell lines and human oral epithelioid cell line was evaluated by the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) and 2,3-bis- [2-methoxy-4-nitro-5-sulfophenyl]-2H-tetrazolium-5-caboxanilide (XTT) methods. 3,4,5-Trihydroxybenzoic acid decreased the cell viability of human oral epithelioid cells and the cell adhesion activity of human oral epithelioid cells. Under the light microscopy, 100 μM 3,4,5-trihydroxybenzoic acid showed the highest cytotoxic activity. From these results, we can propose that 3,4,5-trihydroxybenzoic acid has a potential anticancer activity.
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KEYWORD
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benzoic acid, cell viability, cell adhesion activity, cytotoxicity
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